STRUCTURES REVEAL OPENING OF THE STORE-OPERATED CALCIUM CHANNEL ORAI

The store-operated calcium (Ca2+) channel Orai governs Ca2+ influx through the plasma membrane of many non-excitable cells in metazoans.The channel opens in response to the depletion of Ca2+ stored in the endoplasmic reticulum (ER).Loss- and gain-of-function mutants of Orai cause disease.Our previous work revealed Tote Bag the structure of Orai wit

Background and Faber Daisy B EG6 A55 55cm Angled Cooker Hood Black Glass 330.0529.064 Aim: Heart failure (HF) with reduced ejection fraction (HFrEF) significantly impairs quality of life (QoL), leading to frequent hospitalizations, high mortality and high healthcare costs.This study sought to investigate whether education of patients could enhance